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KMID : 0043319920150030224
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Archives of Pharmacal Research
1992 Volume.15 No. 3 p.224 ~ p.228
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Synthesis of Pyrazolo [4,5]pyridazine and Isoxazolo [3,4d]pyridazine Derivatives
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Abbass IM
Sharaf MAF/El-damaty AA
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Abstract
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Arylhydrazones of diethylacetondicarboxylate 3 was treated with formaldehyde to give 1-aryl-4,5,6-trihydropyridaine derivatives 4a-f Cyclization of compound 4a-f by hydroxylamine afforded [3,4d] 1,3,4,5-tetrahydropyridazine derivatives 5a-f. Also cyclization of compound 4c with semicarbazide gave 1-amidopyrazolo-5-one-1-aryl-3-carboxypyridazine 6. On the other hand compound 3 reacted with ethylorthoformate to give diethyl-1,4-dihydro-1-atylpyridazine-4-one-2,5 dicarboxylate 7, which on treatment with hydrazine, semicarbazide and thiosemicarbazide gave pyridazine, amido and thioamido derivatives. The spectral and antimicrobial data of these compounds 1-8 were studied.
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KEYWORD
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